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SKIN CHANGES AND PECULIARITIES IN PATIENTS WITH METABOLIC SYNDROME

CBU International Conference on Innovation in Science and Education

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Title SKIN CHANGES AND PECULIARITIES IN PATIENTS WITH METABOLIC SYNDROME
 
Creator Janovska, Jana; Riga Stradins University
Zavorins, Aleksejs; Riga Stradins University
Voicehovska, Julija; Riga Stradins University
Kleina, Regina; Riga Stradins University
Kisis, Janis; Riga Stradins University
Karls, Raimonds; Riga Stradins University
Voicehovska, Aleksandra; Latvian University
 
Description Approximately 20-25 % of the World’s adult population aged 40 - 75 years have metabolic syndrome (MS). MS is one of the most widespread risk factors for: diabetes mellitus, cardiovascular disorders and skin disorders MS, due to the oxidative stress, supports a chronic inflammatory reaction in the skin and in the other parts of the body. During oxidative stress the net amount of reactive oxygen species (ROS) exceeds the antioxidant capacity of the body causing lipid peroxidation, protein oxidation and oxidative DNA damage. The role of oxidative stress in pathogenesis of early skin changes in patients with MS is not clearly defined. The aim of our study was to compare visual skin changes between patients with MS and without it, and to reveal early histological manifestations of MS in the skin. The study was conducted at the Clinic of Aesthetic Dermatology, Riga, Latvia. 50 patients aged 45-55 were enrolled. The research consisted of a clinical examination, biochemical testing and Punch biopsies. Tissue samples were stained with haematoxylin-eosin, Masson’s Trichrome and also immunohistochemically stainining with antibodies to CD34, CD117, CD20, CD8 and bcl-2. CD1a positive Langerhans cells were evaluated in 3 fields of vision. Data was analyzed with Microsoft Excel 2010 software. Gender ratio was women: men= 1.6:1. Histological changes in the skin of patients with MS were: hyperkeratosis, acanthosis, dermal fibrosis, elastosis and mild thickening of the stratum spinosum. Infiltrates around blood vessels were composed of T lymphocytes (CD3+). More significant expression and accumulation of apoptotic protein Bcl2 in skin of patients with MS in comparison to patients without MS was noted. Initial skin histological changes in MS are dermal elastosis, thickening of stratum spinosum and acanthosis. Mild T lymphocytic infiltration around capillaries possibly reflects the inflammatory component of MS. Increased accumulation of bcl2 anti-apoptotic protein in epidermis was more significantly expressed in patients with MS. 
 
Publisher Central Bohemia University, o.p.s.
 
Contributor —
 
Date 2013-06-30
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://ojs.journals.cz/index.php/CBUConference2013/article/view/43
10.12955/cbup.2013.43
 
Source CBU International Conference Proceedings; Vol 1 (2013): CBU International Conference Proceedings 2013; pp. 264-271
1805-9961
1805-997X
 
Language eng
 
Relation http://ojs.journals.cz/index.php/CBUConference2013/article/view/43/47
 
Rights Copyright (c) 2013 Jana Janovska, Aleksejs Zavorins, Julija Voicehovska, Regina Kleina, Janis Kisis, Raimonds Karls, Aleksandra Voicehovska
https://creativecommons.org/licenses/by/3.0/