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Analisi di costo di pemetrexed vs docetaxel nel trattamento di seconda linea del carcinoma polmonare non a piccole cellule
Farmeconomia
View Archive Info| Field | Value | |
| Title |
Analisi di costo di pemetrexed vs docetaxel nel trattamento di seconda linea del carcinoma polmonare non a piccole cellule
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| Creator |
Ravasio, Roberto
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| Subject |
Pharmacoeconomics; Health economics
Pemetrexed; Docetaxel; Non-small cell lung cancer; Cost analysis |
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| Description |
OBJECTIVES: to compare costs of pemetrexed versus docetaxel in patients with non-small cell lung cancer previously treated with chemotherapy paying special attention to the adverse events. MATERIALS AND METHODS: a cost analysis was carried out performing comparison between pemetrexed and docetaxel. Clinical data (overall survival) and resource consumption (chemotherapy drugs, G-CSF, and hospitalizations due to adverse events) were obtained from a randomized phase III trial. The economic evaluation was based on direct costs using local Italian unit costs (euro 2005). The perspective was the National Health Service’s. RESULTS: the study results showed that mean survival of pemetrexed (8,3 months; 0,69 years) was higher than mean survival of docetaxel (7,9 months; 0,66 years). The mean cost of treatment with pemetrexed was 8.684,26 euros and with docetaxel was 6.182,87 euros. This difference was nearly offset by the difference in the costs of adverse events: the mean cost of adverse events due to chemotherapy treatment with pemetrexed (493,93 euros) turned out to be lower than with docetaxel (2.394,34 euros). CONCLUSION: the present cost-analysis could be a stable ground for a further cost-utility analysis, aimed at reaching a more cost-effectiveness management of the chemotherapy-related adverse effects in patients with NSCLC.
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| Publisher |
SEEd
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| Date |
2005-06-15
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — |
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| Format |
application/pdf
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| Identifier |
http://journals.edizioniseed.it/index.php/FE/article/view/827
10.7175/fe.v6i2.827 |
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| Source |
Farmeconomia. Health economics and therapeutic pathways; Vol 6, No 2 (2005); 119-126
2240-256X 1721-6915 |
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| Language |
eng
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| Relation |
http://journals.edizioniseed.it/index.php/FE/article/view/827/911
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