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Assessment of the innovative quality of agomelatine through the Innovation Assessment Algorithm
Farmeconomia
View Archive Info| Field | Value | |
| Title |
Assessment of the innovative quality of agomelatine through the Innovation Assessment Algorithm
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| Creator |
Civalleri, Liliana
Licata, Sabrina |
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| Subject |
Health Economics
Agomelatine; IAA; Innovation; Efficacy; Effectiveness |
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| Description |
Aim: the aim of this study was to assess the innovative quality of a medicine based on agomelatine, authorized by the European Commission through a centralized procedure on 19th February 2009 and distributed in Italy under the brands Valdoxan® and Thymanax®.Methodology: the degree of innovation of agomelatine was determined through the Innovation Assessment Algorithm (IAA), which considers the innovative quality of a medicine as a combination of multiple properties. The algorithm may be represented as a decision tree, with each branch corresponding to a property connected with innovation and having a fixed numerical value. The sum of these values establishes the degree of innovation of the medicine. The IAA is articulated in two phases: the first assesses the efficacy of the drug based on the clinical trials presented in support of the registration application (IAA-efficacy); the second reconsiders the degree of innovation on the basis of the efficacy and safety data resulting from clinical practice once the drug has been placed on the market (IAA-effectiveness).Results and conclusions: the score obtained for agomelatine was 592.73 in the efficacy phase and 291.3 in the effectiveness phase. The total score for the two phases was 884, which is equivalent to a good degree of innovation for the molecule
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| Publisher |
SEEd Medical Publishers
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| Contributor |
—
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| Date |
2012-09-21
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — |
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| Format |
text/html
application/pdf |
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| Identifier |
https://journals.edizioniseed.it/index.php/FE/article/view/279
10.7175/fe.v13i3.279 |
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| Source |
Farmeconomia. Health economics and therapeutic pathways; Vol 13, No 3 (2012); 141-152
2240-256X 1721-6915 |
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| Language |
eng
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| Relation |
https://journals.edizioniseed.it/index.php/FE/article/view/279/368
https://journals.edizioniseed.it/index.php/FE/article/view/279/369 |
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| Coverage |
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| Rights |
Copyright (c) 2012 Farmeconomia. Health economics and therapeutic pathways
http://creativecommons.org/licenses/by-nc/4.0 |
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