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[Organizational and financial aspects of the introduction of Botox® in the clinical diagnostic therapeutic process of chronic migraine at a Local Health Unit in Italy]

Farmeconomia. Health Economics and Therapeutic Pathways

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Title [Organizational and financial aspects of the introduction of Botox® in the clinical diagnostic therapeutic process of chronic migraine at a Local Health Unit in Italy]
 
Creator Cioffi, Francesca
Oradei, Marco
Cerbo, Rosanna
Di Pietro, Vittorio
Riccioni, Giovanna
Pardhanani, Gianni
Capannini, Eleonora
Basile, Michele
 
Subject —
OnabotulinumtoxinA; Chronic migraine; Clinical diagnostic therapeutic process
 
Description BACKGROUND: Existing literature shows that the use of Botox®/onabotulinumtoxinA (BT) in chronic migraine (CM) is promising from a cost-effectiveness standpoint and the use of a clinical diagnostic therapeutic process (CDTP) dedicated to CM allows a reduction of pathology costs. The inclusion of BT in chronic migraine therapy at a Roman ASL involves the need to investigate the real treatment costs of a CDTP and to measure how a targeted organizational CDTP strategy for CM allows insuring treatment accessibility, sustainability, and appropriateness.OBJECTIVE: To conduct a cost-effectiveness analysis of providing administration of BT in patients with CM using real world data from an ASL in Rome.METHODS: The real world cost data for approximately 215 anonymous patients were summarized. The cost data were extrapolated from the database of the ASL and they populated a Markov decision model developed by Allergan. The analysis is based on a decision model populated with real drug and service cost data, for the years 2010-2012. The financial assessment was conducted from the viewpoint of the Italian National Health Service.RESULTS: Over a 2 year temporal horizon, incremental BT costs, compared to a placebo, are equal to € 261 against an incremental gain of 0.0655 QALY in favor of BT. The ratio between costs and incremental QALY generates an ICER of 3,983 €/QALY, favorable and below the acceptability threshold used by many countries for reimbursement decisions (25,000-40,000 € per QALY gained).CONCLUSIONS: The inclusion of BT in the CDTP dedicated to CM of an Italian ASL improves both clinical outcomes of the patients and the allocation of the SSN available resources.[Article in Italian]
 
Publisher SEEd Medical Publishers
 
Contributor —
 
Date 2016-10-20
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format text/html
application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/FE/article/view/1262
10.7175/fe.v17i3.1262
 
Source Farmeconomia. Health economics and therapeutic pathways; Vol 17, No 3 (2016)
2240-256X
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/FE/article/view/1262/1575
https://journals.edizioniseed.it/index.php/FE/article/view/1262/1576
 
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Rights Copyright (c) 2016 Farmeconomia. Health economics and therapeutic pathways
http://creativecommons.org/licenses/by-nc/4.0