Since 2014
Inovative Surgical Treatment for Intratubal Administration of Methotrexate
European Journal of Interdisciplinary Studies
View Archive Info| Field | Value | |
| Title |
Inovative Surgical Treatment for Intratubal Administration of Methotrexate
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| Creator |
Tomescu, Aneta
Tomescu, Cezar Laurentiu Sîrbu, Rodica |
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| Description |
In patients where conservative medical treatment with methotrexate failed, surgical intervention was necessary. The personal surgical method was performed on a number of 9 patients; the surgical intervention was a conservative method – salpingorraphy. In order to prevent persistent gestational throphoblastic disease and tubal clogging, a polyethylene catheter is introduced in the oviduct until it reaches the ostium of the Fallopian tube, without exceeding it. In order to ensure a rigorous haemostasis, the Fallopian tube and the polyethylene catheter are sutured together. The level of HCG is measured in the fourth and seventh day postoperative: if the levels of HCG are higher than 1000 mUI/ml, if they plateau or if they have increased, methotrexate is administered intraluminally through the polyethylene tube, according to the following scheme: 50 mg of methotrexate are dissolved in 10 ml of physiological saline solution and injected through the polyethylene catheter, for 5 days. 10 mg per day in 2 doses (5 mg in the morning and 5 mg in the evening).If the values of HCG decrease to an adequate level and there is no risk of persistent throphoblastic disease, the polyethylene catheter is kept for 8-12 days, afterwards it is extracted by traction. If the values do not decrease accordingly, the intraluminal administration of methotrexate is resumed after a 3-day break. This method was used on a number of 9 patients; 4 of them had been treated with methotrexate before the surgical intervention and pertain to the study, and 5 of them had been operated on for complications of ectopic pregnancy and were suitable for this kind of surgical intervention. No postoperative complications or deaths were recorded.
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| Publisher |
EUSER
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| Date |
2015-12-30
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Identifier |
http://journals.euser.org/index.php/ejis/article/view/939
10.26417/ejis.v3i1.p53-58 |
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| Source |
European Journal of Interdisciplinary Studies; Vol 3 No 1 (2015): September-December 2015; 53-58
2411-4138 2411-958X 10.26417/ejis.v3i1 |
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| Language |
eng
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| Relation |
http://journals.euser.org/index.php/ejis/article/view/939/928
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