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Oxidative Stress in Dairy Cows – Serum Paraoxonase Activity Related to Hepatomegaly

Croatian International Relations Review

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Title Oxidative Stress in Dairy Cows – Serum Paraoxonase Activity Related to Hepatomegaly
Oksidacijski stres u mliječnih krava – povezanost aktivnosti paraoksonaze u serumu i povećanja jetre
 
Creator Turk, Romana
Juretić, Dubravka
Gereš, Darko
Turk, Nenad
Simeon-Rudolf, Vera
Rekić, Branka
Svetina, Ante
 
Subject paraoxonase; HDL-cholesterol; oxidative stress; dairy cows; fatty liver
 
Description Association of serum paraoxonase (PON) activity and hepatomegaly in dairy cows as well as the relation between PON activity and HDL cholesterol concentration were studied considering the role of oxidative stress in reproductive and metabolic disorders in dairy caws. A significantly lower PON activity (P<0.01) was found in cows with hepatomegaly compared to clinically healthy cows. Concentrations of serum glucose, triglyceride and cholesterol were also markedly reduced in cows with hepatomegaly (P<0.001, P<0.001 and P<0.05, respectively), whereas the serum HDL cholesterol concentration showed no significant change. Paraoxonase/ HDL-cholesterol ratio in hepatomegaly was significantly lower (P<0.05) as well. As part of antioxidative defence against lipid peroxidation, lower PON activity contributes to an increased risk of oxidative stress in cows with hepatomegaly.
Uzimajući u obzir ulogu oksidacijskoga stresa u reprodukcijskim i metaboličkim poremećajima, istražena je aktivnost paraoksonaze (PON) u serumu mliječnih krava s povećanom jetrom te odnos aktivnosti PON i koncentracije HDL-kolesterola. Utvrđena je značajno manja aktivnost PON u skupini krava s povećanom jetrom u usporedbi s kontrolnom skupinom. Koncentracije glukoze (P<0,001), triglicerida (P<0,001) i kolesterola (P<0,05) bile su također značajno manje u skupini krava s povećanom jetrom nego u skupini zdravih krava. Koncentracija HDL-kolesterola nije se statistički razlikovala između skupina, dok je omjer PON/HDL-kolesterol bio značajno manji (P<0.05) u krava s povećanom jetrom. Smatrajući PON kao dio antioksidacijskoga sustava u sprečavanju peroksidacije lipida, njena niža aktivnost može doprinijeti povećanom riziku od oksidacijskoga stresa u mliječnih krava s povećanom jetrom.
 
Publisher Croatian Chemical Society
 
Date 2005-09-15
 
Type text
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
 
Format application/pdf
 
Identifier http://hrcak.srce.hr/45
http://hrcak.srce.hr/file/45
 
Source Croatica Chemica Acta; Vol.78 No.3; ISSN 0011-1643 (Print); ISSN 1334-417X (Online)
 
Language en
 
Rights info:eu-repo/semantics/openAccess
Parts of the contents of Croat. Chem. Acta (e. g. figures or tables) may be reproduced without prior permission, provided reference is made to their source.