Since 2014
Health-related quality of life in Denmark on a relative scale: mini-catalogue of mean EQ-5D-3L index scores for 17 common chronic conditions
Nordic Journal of Health Economics
View Archive Info| Field | Value | |
| Title |
Health-related quality of life in Denmark on a relative scale: mini-catalogue of mean EQ-5D-3L index scores for 17 common chronic conditions
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| Creator |
Olesen, Anne Vingaard; Danish Centre for Healthcare Improvement Department of Business and Management Aalborg University and The Traffic Research Group Department of Civil Engineering Aalborg University Oddershede, Lars; Danish Centre for Healthcare Improvement Department of Business and Management Aalborg University Petersen, Karin Dam; Danish Centre for Healthcare Improvement Department of Business and Management Aalborg University |
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| Subject |
Economics; Health; Statistics
utility, QALY, EQ-5D-3L, chronic conditions, health economic evaluation, CLAD 1I |
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| Description |
In health economic evaluations the quality-adjusted life-year (QALY) is one of the preferred outcome measures. Catalogues of median-based decrements in EQ-5D-3L index scores for chronic conditions exist to inform economic evaluations but may not be appropriate for this purpose as mean, rather than median, EQ-5D-3L index scores are of primary interest. Firstly, we aim to estimate mean decrements in EQ-5D-3L index scores through a simple stratified analysis as an alternative to regression modelling. In addition, we aim to estimate the mean decrement in EQ-5D-3L index scores in percent relative to a disease-free reference population. Secondly, we aim to handle both multiple imputation and appropriate estimation of standard errors in the presence of individual sampling weights. Data on EQ-5D-3L from the National Health Profile, Denmark, 2013, were used to estimate the EQ-5D-3L index scores. Calculation of decrements in EQ-5D-3L index scores of chronic conditions was done while controlling for the additional number of chronic conditions beside the one in question, age and sex. Also, a test of homogeneity of decrements across subgroups was conducted. We provide a mini-catalogue of new percentage-scale decrements in EQ-5D-3L index scores. For example, we estimated that angina was associated with an 8.2% reduction in the EQ-5D-3L index score compared to a reference group without angina. If the mean EQ-5D-3L score was 0.848 among corresponding groups without angina; angina patients would have an EQ-5D-3L index score of (1-0.082)·0.848=0.778 using the percentage-scale. The estimated percentage reduction in the EQ-5D-3L index score was homogenous regardless of the number of additional chronic conditions, age and sex. We suggest a percentage-scale estimation of EQ-5D-3L index scores for chronic disorders as an alternative to existing median-based methods. Our estimates stem from a simpler model, which, we argue, is easier to use and interpret.Published: Online May 2016. In print August 2016.
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| Publisher |
University of Oslo
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| Contributor |
Department of Business and Management, Aalborg University
The North Denmark Region |
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| Date |
2016-08-13
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion Peer-reviewed Article |
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| Format |
application/pdf
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| Identifier |
https://www.journals.uio.no/index.php/NJHE/article/view/2413
10.5617/njhe.2413 |
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| Source |
Nordic Journal of Health Economics; Vol 4, No 2 (2016): Nordic Journal of Health Economics; pp. 44-56
1892-9710 1892-9729 |
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| Language |
eng
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| Relation |
https://www.journals.uio.no/index.php/NJHE/article/view/2413/3071
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| Rights |
Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
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