Since 2014
A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations
Farmeconomia
View Archive Info| Field | Value | |
| Title |
A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations
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| Creator |
Bellone, Marco
Sbarra, Pierluigi |
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| Subject |
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Hypertension, Fixed-dose combinations, Cost-minimization analysis |
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| Description |
BACKGROUND: Cardiovascular disease management and prevention represent the leading cost driver in Italian healthcare expenditure. In order to reach the target blood pressure, a large majority of patients require simultaneous administration of multiple antihypertensive agents.OBJECTIVE: To assess the economic impact of the use of fixed dose combinations of antihypertensive agents, compared to the extemporary combination of the same principles.METHODS: A cost minimization analysis was conducted to determine the pharmaceutical daily cost of five fixed dose combinations (olmesartan 20 mg + amlodipine 5 mg, perindopril 5 mg + amlodipine 5 mg, enalapril 20 mg + lercanidipine 10 mg, felodipine 5 mg + ramipril 5 mg, and delapril 30 mg + manidipine 10 mg) compared with extemporary combination of the same principles in the perspective of the Italian NHS. Daily acquisition costs are estimated based on current Italian prices and tariffs.RESULTS: In three cases the use of fixed‑dose combination instead of extemporary combination induces a lower daily cost. Fixed combination treatment with delapril 30 mg + manidipine 10 mg induces greater cost savings for the National Health System (95,47 €/pts/year), as compared to free drugs combination therapy.CONCLUSIONS: Compared with free drug combinations, fixed‑dose combinations of antihypertensive agents are associated with lower daily National Health Service acquisition costs.
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| Publisher |
SEEd
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| Contributor |
Il presente lavoro è stato realizzato con il supporto di Bracco
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| Date |
2013-12-18
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| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — |
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| Format |
text/html
application/pdf |
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| Identifier |
http://journals.edizioniseed.it/index.php/FE/article/view/886
10.7175/fe.v14i4.886 |
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| Source |
Farmeconomia. Health economics and therapeutic pathways; Vol 14, No 4 (2013); 153-160
2240-256X 1721-6915 |
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| Language |
eng
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| Relation |
http://journals.edizioniseed.it/index.php/FE/article/view/886/1022
http://journals.edizioniseed.it/index.php/FE/article/view/886/1023 |
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