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Tramadolo: profilo farmacologico, terapeutico e farmacoeconomico

Farmeconomia

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Title Tramadolo: profilo farmacologico, terapeutico e farmacoeconomico
 
Creator Serpe, Loredana
Pradelli, Lorenzo
Eandi, Mario
 
Subject Pharmacoeconomics; Health economics
 
Description Tramadol is an effective central analgesic with a dual mechanism of action: antagonism on mu-opioid receptors and inhibition of serotonin and norepinephrine reuptake. In this paper a pharmacological, clinical and economical profile of its use in pain management is provided. Tramadol has proven effective in the treatment of moderate and severe pain associated with acute and chronic conditions of different ethiology, at oral or parenteral doses of about 50-100 mg every 4-6 hours. The maximal daily dose should not exceed 400 mg, less in case of liver or kidney dysfunction. Tramadol has low potential for physical or psychological dependence; the minimal likelihood of provoking typical opioid adverse events represents an advantage over other morphine-like agents. From a pharmacoeconomical point of view, tramadol prescription appears to be efficient: the comparisons conducted in the management of post-surgical pain have shown tramadol to be more convenient than the studied alternatives. Overall, tramadol appears to be a safe and effective drug for the management of pain and it is one of the most relevant week opioids to be used in the second step of the pain management latter proposed by the WHO. The recent introduction of generic tramadol permits to choose among more products and allows to obtain savings on the cost of managing acute and chronic painful conditions.
 
Publisher SEEd Medical Publishers
 
Date 2004-09-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier https://journals.edizioniseed.it/index.php/FE/article/view/794
10.7175/fe.v5i3.794
 
Source Farmeconomia. Health economics and therapeutic pathways; Vol 5, No 3 (2004); 151-162
2240-256X
 
Language eng
 
Relation https://journals.edizioniseed.it/index.php/FE/article/view/794/890
 
Rights Copyright (c) 2004 Farmeconomia. Health economics and therapeutic pathways
http://creativecommons.org/licenses/by-nc/4.0