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Tigecycline: a review of the literature

Farmeconomia

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Title Tigecycline: a review of the literature
 
Creator Venditti, Mario
Pompeo, Maria Elena
Fabi, Flavia
 
Subject Pharmacoeconomics; Health economics
Tigecycline; Glycylcycline; Broad-spectrum antibiotics; Bacterial infections
 
Description Tigecycline is a new first-in-class glycylcycline antimicrobial agent with expanded broad-spectrum activity. It was developed to overcome the two key resistance mechanisms, efflux pumps and ribosomal protection, that limit the use of tetracycline. The spectrum of activity extends to clinically relevant susceptible and multidrug resistant bacteria, as methicillin resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, vancomycin resistant Enterococci, Acinetobacter spp, Acinetobacter baumannii and Enterobacteriaceae, including extended-spectrum β-lactamase-producing strains (ESBLs). Tigecycline has been introduced into clinical practice as part of the effort to combat the growing problem of bacterial resistance to anti-infective therapy: tigecycline could replace some broad-spectrum agents for approved indications reducing the selective pressure provided by antibiotic administration. The expanded in vitro activity against a broad range of bacteria, including resistant pathogens, of tigecycline suggest that this novel antimicrobial agent should offer clinicians an option for the treatment of patients with serious bacterial infections.
 
Publisher SEEd
 
Contributor —
 
Date 2006-01-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://journals.edizioniseed.it/index.php/FE/article/view/256
10.7175/fe.v7i4.256
 
Source Farmeconomia. Health economics and therapeutic pathways; Vol 7, No 4 (2006); 211-222
2240-256X
1721-6915
 
Language eng
 
Relation http://journals.edizioniseed.it/index.php/FE/article/view/256/238
 
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