Since 2014
Valutazione economica dello studio AVERT
Farmeconomia
View Archive Info| Field | Value | |
| Title |
Valutazione economica dello studio AVERT
|
|
| Creator |
De Portu, Simona
Cammarota, Simona Menditto, Enrica Mantovani, Lorenzo G. |
|
| Subject |
Pharmacoeconomics; Health economics
Atorvastatin; Angioplasty; Coronary disease; Cost; Italian National Health System |
|
| Description |
Introduction: the AVERT study (“Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease”) compared aggressive cholesterol-lowering (with the statin atorvastatin) to angioplasty in patients with mild to moderate coronary artery disease. Aim: our aim was to investigate the economic consequence of high dose of atorvastatin vs percutaneous coronary revascularization followed by standard therapy in Italian patients with stable coronary artery disease Methods: clinical information were taken from the AVERT study. We conducted a cost-effectiveness analysis, comparing high dose of atorvastatin (80 mg/die) versus angioplasty in the perspective of the Italian National Health Service. We identified and quantified medical costs: drug costs according to the Italian National Therapeutic Formulary and hospitalizations were quantified based on the Italian National Health Service tariffs (2006). Effects were measured in terms of mortality and morbidity reduction (number of deaths, life years gained and frequency of hospitalizations). We considered an observation period of 18 months. The costs borne after the first 12 months were discounted using an annual rate of 3%. We conducted one and multi-way sensitivity analyses on unit cost and effectiveness. We also conducted a threshold analysis. Results: the cost of atorvastatin therapy or angioplasty over the 18 months period amounted to approximately 779 euro and 5.5 millions euro per 1,000 patients respectively. Atorvastatin was more efficacious compared to angioplasty and the overall cost of care per 1,000 patients over 18 months of follow-up was estimated at 1.8 millions euro in the atorvastatin group and 7.2 millions euro in the angioplasty group, resulting into a cost saving of 5.4 millions euro that is 74,9% of total costs occurred in the angioplasty group. Discussion: this study demonstrates that high does atorvastatin treatment leads to a reduction of direct costs for the National Health System if compared to angioplastic treatment. Atorvastatin therapy is dominant since it is both less costly and more effective than angioplasty. Results of sensitivity analysis showed that atorvastatin therapy remains dominant even in the most unfavourable hypotheses. |
|
| Publisher |
SEEd
|
|
| Date |
2007-10-15
|
|
| Type |
info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion — |
|
| Format |
application/pdf
|
|
| Identifier |
http://journals.edizioniseed.it/index.php/FE/article/view/1028
10.7175/fe.v8i2S.1028 |
|
| Source |
Farmeconomia. Health economics and therapeutic pathways; Vol 8, No 2S (2007); 31-35
2240-256X 1721-6915 |
|
| Language |
eng
|
|
| Relation |
http://journals.edizioniseed.it/index.php/FE/article/view/1028/1247
|
|